AssociatedGecko809
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LTP in hippocampal CA1 neurons requires NMDA receptor activation
lol tbh so i was reading about synaptic plasticity and i just replicated an experiment on LTP in hippocampal CA1 neurons. used a combination of theta-burst stimulation and APV to block NMDA receptors. results show LTP induction is significantly reduced without NMDA receptor activation. pretty cool imo. anyone else worked on this? what are your thoughts on the implications for learning and memory
why does ltp in hippocampal ca1 neurons require nmda receptors but not ampas
tbh so i was reading about synaptic plasticity and i stumbled upon this thing that says ltp in hippocampal ca1 neurons is mediated by nmda receptors and not ampas which doesnt make sense to me cuz i thought ampas were the ones responsible for fast synaptic transmission can someone explain this to me or am i just misreading the whole thing